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Hybrid Human-Animal Embryo Research Approved In The UK




Two research groups in the United Kingdom have been given permission to use hybrid human-animal embryos in research which aims to lead to the development of new therapies for debilitating human conditions such as Parkinson's disease and stroke.


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Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study
Background: The placenta is an important site for iron metabolism in humans. It transfers iron from the mother to the fetus. One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake. Its localization and expression may be one of the markers to distinguish placental dysfunction. Methods: In the experimental study we used antibody preparation, mass spectrometric analysis, biochemical and immunocytochemical methods for characterization of transferrin expression on the human choriocarcinoma cell line JAR (JAR cells), placental lysates, and cryostat sections. Newly designed monoclonal antibody TRO-tf-01 to human transferrin was applied on human placentae from normal (n = 3) and abnormal (n = 9) pregnancies. Results: Variations of transferrin expression were detected in villous syncytiotrophoblast, which is in direct contact with maternal blood. In placentae from normal pregnancies, the expression of transferrin in the syncytium was significantly lower (p < 0.001) when compared to placentae from abnormal ones (gestational diabetes, pregnancy induced hypertension, drug abuse). Conclusion: These observations suggest that in the case of abnormal pregnancies, the fetus may require higher levels of transferrin in order to prevent iron depletion due to the stress from the placental dysfunction.
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Impact of depression on HIV outcomes in the HAART era

Highly active antiretroviral therapy (HAART) has significantly decreased the morbidity and mortality of persons infected with HIV. The extent of the benefits, however, is not uniform, and certain factors including ethnicity, gender, baseline HIV viral load and CD4+ T lymphocyte count, adherence and intravenous drug abuse are associated with different immunological, virological and clinical outcomes. Mental health illness (MHI) and specifically depression may be associated with worse outcomes, although studies exploring the impact of MHI on HIV outcomes in both the pre-HAART and post-HAART eras have shown mixed results. The objective of the current paper is to review the available literature on the impact of MHI on HIV outcomes in the HAART era.

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A Colorful Approach to Solar Energy
Revisiting a once-abandoned technique, engineers at the Massachusetts Institute of Technology (MIT) have successfully created a sophisticated, yet affordable, method to turn ordinary glass into a high-tech solar concentrator. (2008-07-11)
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Ekkyo Describes the First Benefits of Controlled Hyperthermia in Humans in "Lasers in Surgery and Medicine"
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Antibody Methods and Techniques
Includes antibody search, methods, techniques, protocols, reviews, books, and discussion forums.
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Stereo Microscopes with Dual Magnification, Fixed Objectives
Choose among quality low power stereo microscopes featuring dual magnification, fixed objectives. Discount prices! ... Stereo Microscopes Low ...
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ScienceDaily: Cloning News
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