Stereo Dissecting Microscope

all about Stereo Dissecting Microscope
Stereo Dissecting Microscope Resources

Home > Stereo Dissecting Microscope > Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report

Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report



Background: We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes. Sardinia has an unusual distribution of haplotypes and genotypes, with the highest population frequency of HLA DR3 in the world, and after Finland, the highest prevalence of Type 1 diabetes and Autoimmune-related Diseases. In this study we preliminarily tested the prevalence of serological markers of Type 1 diabetes in a group of Sardinian GDM patients. Methods: We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity. Results: We found a high prevalence and very unusual distribution of antibodies in GDM patients (38.8%), the anti-IA2 being the most frequent antibody. Out of all our GDM patients, 38.8% (24 of 62) were positive for at least one antibody. Anti-IA2 was present in 29.0 % (18 out of 62) vs. 7.1% (4 out of 56) in the controls (P < 0.001). IAA was present in 14.5% (9 out of 62) of our GDM patients, and absent in the control subjects (P < 0.001). Anti-GAD65 was also present in GDM patients, with a prevalence of 3.2% (2 out of 62) while it was absent in the control group (P = NS). Pre-gestational weight was significantly lower (57.78 ± 9.8 vs 65.9 ± 17.3 P = 0.04) in auto-antibodies- positive GDM patients. Conclusion: These results are in contrast with the very low prevalence of all antibodies reported in Italy. If confirmed, they could indicate that a large proportion of GDM patients in Sardinia have an autoimmune origin, in accordance with the high prevalence of Type 1 diabetes.


Click Here to read the entire article...



Other Articles:


• Clones On Task Serve Greater Good, Evolutionary Study Shows
"Don't ever change" isn't just a romantic platitude. It's a solid evolutionary strategy. Creatures that produce scads of genetically identical offspring -- like microbes, plants or water fleas -- offer answers about the clones raised in near-identical environments that turn out differently than their kin. How is the greater good of a genetic pool of identical organisms affected when a few individuals break from the developmental pack?
Click Here to read the entire article...
• Turkey: a further country concerned by community-acquired Escherichia coli clone O25-ST131 producing CTX-M-15
Objectives

The aim of this study was to assess the frequency and diversity of extended-spectrum β-lactamases (ESBLs) produced by exclusively community-acquired Escherichia coli isolates in Izmir (Turkey) and to search for isolates producing CTX-M-15 and belonging to the pandemic clone E. coli O25-ST131.

 Methods

The patients with E. coli urinary tract infections (UTIs) and no hospitalization in the last 12 months, and no transfer from hospital, no stay in nursing home and no antimicrobial treatment in the previous 3 months were prospectively included over a 1 year period. Those E. coli detected positive for ESBL were characterized and compared with a representative of E. coli clone O25-ST131 with regard to bla genes, antibiotic resistance, phylogenetic groups, PFGE profiles and virulence factor genes (n = 17). O serotyping, multilocus sequence typing (MLST) and AmpC typing were performed to confirm that the Turkish isolate belonged to the clone O25-ST131.

 Results

Among the 3108 UTIs diagnosed, 82 (2.6%) were due to community E. coli isolates and followed the strict inclusion criteria. Seventeen of them (21%) produced an ESBL, of which CTX-M-15 was predominant (53%). These ESBL-positive isolates, distributed equally into three phylogenetic groups, displayed 13 PFGE profiles and three clusters. A Turkish CTX-M-15-producing isolate as a member of the clone ST131 was suggested by a high similarity of its PFGE profile to that of the clone representative and was confirmed by O serotyping, AmpC typing and MLST.

 Conclusions

This study describes the community emergence of CTX-M-15-producing E. coli isolates, including an isolate of clone O25-ST131, in Turkey.
Click Here to read the entire article...
•
Click Here to read the entire article...
• Vertos Medical Inc. Presents Clinical Data of its MILD&#8482; Procedure at the 5th Annual Innovative Techniques in Spine Surgery Conference in Los Cabos, Mexico
Click Here to read the entire article...
• Articulating Microscopes
A website dedicated to Articulating Microscopes. Get the latest articles, news and information updates on Articulating Microscopes from Articulating Microscopes.
Click Here to read the entire article...
• Meiji Stereo Microscopes
Meiji Stereo Microscopes for the professional. ... Meiji Stereo Microscopes . There are several ways to choose a Meiji Stereo Microscope.
Click Here to read the entire article...
Reproductive Biology and Endocrinology - Latest articles
- Copyright © 2008 Microsoft. All rights reserved. These XML results may not be used, reproduced or transmitted in any manner or for any purpose other than rendering Live Search results within an RSS aggregator for your personal, non-commercial use. Any other use of these results requires express written permission from Microsoft Corporation. By accessing this web page or using these results in any manner whatsoever, you agree to be bound by the foregoing restrictions. - version: v1.5 build A